The use of proteasome inhibitors to treat cancer has been greatly limited by the ability of cancer cells to develop resistance to these drugs. But researchers have found a mechanism underlying this resistance -- a mechanism that naturally occurs in many diverse cancer types and that may expose vulnerabilities to drugs that spur the natural cell-death process.
Naturally occurring mechanism of cancer drug-resistance may itself be a treatment target
Science Daily - 27 Dec 2016 04:09
The use of proteasome inhibitors to treat cancer has been greatly limited by the ability of cancer cells to develop resistance to these drugs. But researchers have found a mechanism underlying this resistance -- a mechanism that naturally occurs in many diverse cancer types and that may expose vulnerabilities to drugs that spur the natural cell-death process.
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